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Dimethylisopropylsilyl ether derivatives in gas chromatography mass spectrometry of hydroxylated steroids
Author(s) -
Miyazaki Hiroshi,
Ishibashi Masataka,
Yamashita Kouwa
Publication year - 1979
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200060204
Subject(s) - ether , chemistry , polyatomic ion , mass spectrum , mass spectrometry , isopropyl , ion , chromatography , gas chromatography , gas chromatography–mass spectrometry , organic chemistry
The gas chromatographic mass spectrometric properties of the dimethylisopropylsilyl ether derivatives of 27 hydroxysteroids have been studied. The retention times of the dimethylisopropylsilyl ether derivates were close to those of the dimethyl‐ n ‐propylsilyl ether derivatives. The mass spectra were characterized by their marked simplicity and the molecular ion cluster, [M] + ˙, [M–15] + and [M–43] + . The [M–43] + ion, corresponding to loss of the isopropyl group from the molecular ion in these derivatives, was very intense and was frequently observed as a principal ion. In particular, it was found as a principal ion in the DMiPS ether derivatives of pregnanediols.