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The identification of Ibuprofen and analogues in urine by pyrolysis gas chromatography mass spectrometry
Author(s) -
Irwin W. J.,
Slack J. A.
Publication year - 1978
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200051204
Subject(s) - chemistry , chromatography , ibuprofen , urine , naproxen , mass spectrometry , ketoprofen , decarboxylation , gas chromatography–mass spectrometry , gas chromatography , pyrolysis , yield (engineering) , organic chemistry , pharmacology , biochemistry , catalysis , materials science , medicine , alternative medicine , pathology , metallurgy
The pyrolysis gas chromatography mass spectrometry of Ibuprofen, Fenoprofen, Naproxen and Ketoprofen, a series of anti‐inflammatory propionic acid derivatives, is shown to proceed via decarboxylation and elimination to yield characteristic ethyl and vinyl fragments. The program enables the identification of the drug to be achieved as the pure compound, in a formulated dosage form or excreted in urine. The presence of metabolites derived from Ibuprofen causes four new fragments to be observed in the urine pyrogram. The identification of 16 components of the control urine pyrogram is presented.