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Selected ion monitoring assay for meclizine in human plasma
Author(s) -
Fouda Hassan G.,
Falkner Fred C.,
Hobbs Donald C.,
Luther Elbridge W.
Publication year - 1978
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200050806
Subject(s) - human plasma , chemistry , chromatography
Abstract A method has been developed for the quantification of meclizine in human plasma using gas chromatography mass spectrometry. Pentadeuterated meclizine was synthesized and used as an internal standard. The method gave linear results over a concentration range of 5–200 ng ml −1 and was used to determine plasma levels of meclizine following administration to a male volunteer.