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Determination of isamoxole ( N ‐butyl‐ N ‐(4‐methyloxazol‐2‐yl)‐2‐methylpropanamide, LRCL 3950) in plasma by selected ion monitoring using a stable isotope internal standard
Author(s) -
Chatfield David H.,
Woodage Trevor J.
Publication year - 1978
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200050709
Subject(s) - deuterium , plasma , ion , chemistry , isotope , analytical chemistry (journal) , radiochemistry , chromatography , organic chemistry , atomic physics , nuclear physics , physics
Abstract A selected ion monitoring method for the estimation of an anti‐allergy compound isamoxole ( N ‐butyl‐ N ‐(4‐methyloxazol‐2‐yl)‐2‐methylpropanamide, LRCL 3950) in plasma has been developed. The method uses a stable isotope analogue containing nine deuterium atoms as internal standard. The assay is sensitive to 2 ng ml −1 plasma and has been used to examine plasma levels of isamoxole after oral doses of the compound to animals and man.