Determination of isamoxole ( N ‐butyl‐ N ‐(4‐methyloxazol‐2‐yl)‐2‐methylpropanamide, LRCL 3950) in plasma by selected ion monitoring using a stable isotope internal standard | Zendy

Chatfield David H. | Zendy; Woodage Trevor J. | Zendy

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Determination of isamoxole ( N ‐butyl‐ N ‐(4‐methyloxazol‐2‐yl)‐2‐methylpropanamide, LRCL 3950) in plasma by selected ion monitoring using a stable isotope internal standard

Author(s) -

Chatfield David H.,

Woodage Trevor J.

Publication year - 1978

Publication title -

biomedical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0306-042X

DOI - 10.1002/bms.1200050709

Subject(s) - deuterium , plasma , ion , chemistry , isotope , analytical chemistry (journal) , radiochemistry , chromatography , organic chemistry , atomic physics , nuclear physics , physics

A selected ion monitoring method for the estimation of an anti‐allergy compound isamoxole ( N ‐butyl‐ N ‐(4‐methyloxazol‐2‐yl)‐2‐methylpropanamide, LRCL 3950) in plasma has been developed. The method uses a stable isotope analogue containing nine deuterium atoms as internal standard. The assay is sensitive to 2 ng ml −1 plasma and has been used to examine plasma levels of isamoxole after oral doses of the compound to animals and man.

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