Premium
A ‘carrier effect’ observed in assays for antidiarrhoeal drug compounds
Author(s) -
Haskins N. J.,
Ford G. C.,
Grigson S. J. W.,
Waddell K. A.
Publication year - 1978
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200050610
Subject(s) - antidiarrhoeal , chemistry , drug , dilution , chromatography , isotope dilution , pharmacology , stereochemistry , medicine , organic chemistry , mass spectrometry , physics , castor oil , thermodynamics
A carrier effect has been shown to exist in a stable isotope dilution assay for diphenoxylate. When a tetradeuterated analogue is used as a carrier and internal standard a sevenfold increase in sensitivity is observed for the unlabelled compound. Examination of a related pharmacologically active compound (SC‐27166) showed a much smaller effect.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom