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Mass spectrometry and gas chromatography of trimethylsilyl derivatives of catecholamine related molecules
Author(s) -
Hattox Susan E.,
Murphy Robert C.
Publication year - 1978
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200050505
Subject(s) - trimethylsilyl , chemistry , mass spectrum , gas chromatography , electron ionization , molecule , mass spectrometry , methylene , fragmentation (computing) , chromatography , deuterium , kovats retention index , gas chromatography–mass spectrometry , amino acid , ion , organic chemistry , biochemistry , physics , quantum mechanics , computer science , ionization , operating system
The trimethylsilyl derivatives of approximately 50 compounds related in structure to biogenic catecholamines have been studied in terms of their gas chromatographic and mass spectrometric behavior. The electron impact mass spectra of the trimethylsilyl derivatives of 3,4‐dihydroxyphenylethylamine, 3,4‐dihydroxyphenylacetic acid and 3,4‐dihydroxyphenylethylamine and deuterated isotopic variants were compared to determine fragmentation characteristics of the amines, acids, alcohols and amino acids within this class of compounds. Analysis of shifts in the masses of major diagnostic ions in the spectra of structural analogs of these compounds has shown that structural modification of the structure can be identified and localized within these molecules. The gas chromatographic characteristics of these derivatives are reported, in terms of methylene unit values.