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Profiles in altered metabolism. II—Accumulation of homogentisic acid in serum and urine following acetylsalicylic acid ingestion
Author(s) -
Montgomery J. A.,
Mamer O. A.
Publication year - 1978
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200050503
Subject(s) - homogentisic acid , urine , ingestion , chemistry , urinary system , excretion , metabolism , in vivo , medicine , oxidase test , endocrinology , biochemistry , enzyme , biology , microbiology and biotechnology
Homogentisic acid elevations have been found in urine and serum of patients on long term heavy salicylate therapy and those acutely intoxicated with acetylsalicylic acid. Loading of two normal volunteers with single oral acetylsalicylate doses produced transient elevations in urinary homogentisic acid excretion. These findings suggest that heavy salicylate use results in the partial inhibition of homogentisic acid oxidase in vivo .