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Pharmacokinetics of nabilone, a psychotropically active 9‐ketocannabinoid, in the dog. Utilization of quantitative selected ion monitoring and deuterium labeling
Author(s) -
Sullivan H. R.,
Kau D. L. K.,
Wood P. G.
Publication year - 1978
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200050405
Subject(s) - pharmacokinetics , chemistry , deuterium , chromatography , coefficient of variation , pharmacology , medicine , physics , quantum mechanics
Quantitative selected ion monitoring methods for the determination of plasma concentrations of nabilone, a psychotropically active 9‐ketocannabinoid, and two carbinol metabolites using deuterium labeled internal standards are described. These specific methods have a lower limit of sensitivity of about 2 pmol ml −1 with a coefficient of variation of less than 4%. The utility of these methods was demonstrated by in vivo studies of single dose and steady state pharmacokinetics of nabilone and its carbinol metabolites in the dog.