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Profiles in altered metabolism. I—The organic acids accumulating in acute non‐diabetic ketoacidosis associated with alcoholism
Author(s) -
Mamer O. A.,
Montgomery J. A.,
Tjoa S. S.,
Crawhall J. C.,
Feldkamp C. S.
Publication year - 1978
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200050403
Subject(s) - diabetic ketoacidosis , ketoacidosis , catabolism , medicine , endocrinology , thiamine , metabolism , acetaldehyde , thiamine pyrophosphate , diabetes mellitus , urine , chemistry , biochemistry , cofactor , ethanol , type 1 diabetes , enzyme
Several organic acids, among them the acidic catabolites of the branched chain amino acids and tyrosine, have been found to be elevated in the sera of non‐diabetic patients presenting acute ketoacidosis associated with alcohol abuse. These findings are interpreted in terms of insufficiency of dietary co‐factors required for their further catabolism. Butane‐2,3‐diol is also found frequently elevated in the urine of these patients and suggests interception of hydroxyethyl thiamine pyrophosphate by circulating high levels of acetaldehyde.