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Some considerations on quantitative methodology and detection limits in organic mass spectrometry
Author(s) -
Marshall Donald J.,
Petersen Bruce A.,
Vouros Paul
Publication year - 1978
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200050314
Subject(s) - detection limit , reproducibility , mass spectrometry , chromatography , chemistry , calibration , analytical chemistry (journal) , mathematics , statistics
Mass spectrometric sensitivity data for the compounds cholesterol, cholestane, DDT, decafluorotriphenyl‐phosphine, morphine, LSD and methyl stearate have been developed over a period of time and under a variety of conditions. This information is presented on both a relative and an absolute basis. With the exception of morphine, relative sensitivities were repoducible to within a factor of three over a six month period. This reproducibility facilitates quantitation and a single standard can be used for calibration of organic compounds from various classes. Detection limits of 50 femtograms for LSD are realized for samples introduced via the direct inlet probe.