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Determination of vincamine in plasma by selected ion monitoring
Author(s) -
Hoppen H.O.,
Heuer R.,
Seidel G.
Publication year - 1978
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200050207
Subject(s) - ion , plasma , chemistry , physics , nuclear physics , organic chemistry
A sensitive and specific method for the determination of vincamine in plasma is described. The molecular ion ( m / e 426) and the parent peak ( m / e 367) of the TMS derivative are assayed simultaneously by selected ion monitoring. Sensitivity is 30 pg per ml plasma. The suitability of the method for pharmacokinetic studies is assessed by measuring plasma level profiles in six volunteers receiving 20 mg of vincamine orally.