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The proximo‐distal carcinogen N ‐hydroxy‐2‐fluorenylacetamide, toxification and detoxification routes due to electrophilic and combined nucleophilic and electrophilic tautomerism effects
Author(s) -
Lhoest G.,
Roberfroid M.,
Mercier M.
Publication year - 1978
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200050108
Subject(s) - electrophile , detoxification (alternative medicine) , nucleophile , chemistry , tautomer , medicinal chemistry , organic chemistry , medicine , catalysis , alternative medicine , pathology
The importance of certain ring chain tautomerism effects in chemical carcinogenesis is discussed and the concept of a proximo‐distal carcinogen is defined.