The formation of cyclized silyl derivatives of β‐hydroxyamines and their analyses by means of gas chromatography mass spectrometry

A generally applicable silylation method for β‐hydroxyalated primary, secondary, tertiary and even quaternary amines is presented. These aminoalcohols form 6‐membered heterocycles under the influence of a reagent mixture consisting of 1,3‐bis‐(chloromethyl)‐1,1,3,3‐tetramethyldisilazane and chloromethyldimethyl‐chlorosilane. Examples of analogue ring closures with a γ‐hydroxyamine and an α‐amino acid are also given. The formation of the derivatives and their properties, are discused, mainly from the viewpoint mass spectrometry.