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The formation of cyclized silyl derivatives of β‐hydroxyamines and their analyses by means of gas chromatography mass spectrometry
Author(s) -
Hammar CarlGustaf
Publication year - 1978
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200050105
Subject(s) - silylation , chlorosilane , mass spectrometry , reagent , chemistry , primary (astronomy) , gas chromatography–mass spectrometry , gas chromatography , ring (chemistry) , organic chemistry , chromatography , catalysis , physics , astronomy , silicon
A generally applicable silylation method for β‐hydroxyalated primary, secondary, tertiary and even quaternary amines is presented. These aminoalcohols form 6‐membered heterocycles under the influence of a reagent mixture consisting of 1,3‐bis‐(chloromethyl)‐1,1,3,3‐tetramethyldisilazane and chloromethyldimethyl‐chlorosilane. Examples of analogue ring closures with a γ‐hydroxyamine and an α‐amino acid are also given. The formation of the derivatives and their properties, are discused, mainly from the viewpoint mass spectrometry.