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The gas chromatography mass spectrometry of the major metabolites of flurazepam
Author(s) -
Clatworthy A. J.,
Jones L. V.,
Whitehouse M. J.
Publication year - 1977
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200040411
Subject(s) - flurazepam , chromatography , chemistry , metabolite , mass spectrometry , acetic acid , gas chromatography , gas chromatography–mass spectrometry , organic chemistry , biochemistry , receptor , benzodiazepine
Mass spectra and gas chromatographic data are presented for flurazepam and its metabolites; monodesethyl flurazepam, didesethylflurazepam, hydroxyethylflurazepam, N 1 ‐desalkylflurazepam, N 1 ‐desalkyl‐3‐hydroxy flurazepam, and flurazepam‐ N 1 ‐acetic acid. The on‐column thermal degradation of didesethylflurazepam, N 1 ‐desalkyl‐3‐hydroxyflurazepam and flurazepam‐ N 1 ‐acetic acid is reported and discussed. Mass spectrometric and gas chromatographic data are also presented for the benzophenones obtained by acid hydrolysis of flurazepam and its metabolites. The occurrence of flurazepam metabolites in urine from five forensic cases after various treatments has been investigated. A possible new ‘metabolite’ of flurazepam was detected in two of these cases.