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Synthesis and characterization of glucuronides of cannabinol, cannabidiol, Δ 9 ‐tetrahydrocannabinol and Δ 8 ‐tetrahydrocannabinol
Author(s) -
Lyle Michael A.,
Pallante Sharon,
Head Ken,
Fenselau Catherine
Publication year - 1977
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200040313
Subject(s) - cannabinol , cannabidiol , chemistry , tetrahydrocannabinol , chromatography , glucuronide , trimethylsilyl , organic chemistry , cannabinoid , metabolite , biochemistry , cannabis , psychology , receptor , psychiatry
Partially purified glucuronyltransferase immobilized on beaded sepharose has been used to synthesize the glucuronide conjugates of cannabidol, cannabidol, Δ 9 ‐tetrahydrocannabinol and Δ 8 ‐tetrahydrocannabinol. Trimethylsilylated methyl esters and per(trimethylsilyl) derivatives of these conjugates have been characterized by their gas chromatographic retention times and their electron impact and ammonia chemical ionization mass spectra.