Premium
Location of functional groups in antipyrine metabolites by mass spectrometry
Author(s) -
Zietz Eberhard,
Spiteller Gerhard
Publication year - 1977
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200040307
Subject(s) - substituent , fragmentation (computing) , chemistry , mass spectrometry , mass spectrum , stereochemistry , position (finance) , chromatography , computer science , operating system , finance , economics
The mass spectra of antipyrine metabolites show characteristic fragmentation patterns which depend on the presence and position of functional groups. A substituent at position 4 is indicated by an intense key fragment at m / e 56 and a substituent at the methyl group in position 3 causes a significant increase in the intensity of the peak at m / e 82. The fragment at m / e 96, which is characteristic for antipyrine itself, is suppressed if there is a substituent in either position 3 or 4. Mass spectra of the glucuronides of 4‐hydroxyantipyrine and 3‐hydroxymethylantipyrine are also discussed.