Premium
The measurements of propantheline ion in biological fluids after administering propantheline bromide to man
Author(s) -
Ford G. C.,
Grigson S. J. W.,
Haskins N. J.,
Palmer R. F.,
Prout M.,
Vose C. W.
Publication year - 1977
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200040207
Subject(s) - bromide , chemistry , ion , urine , chromatography , inorganic chemistry , organic chemistry , biochemistry
The measurement of propantheline ion has been accomplished in urine and plasma following administration of propantheline bromide to man. Trideuteropropantheline bromide is added to the biological fluid to act as a carrier and internal standard to quantify the propantheline ion using multiple ion monitoring. Methane was used as reactant gas but following the discovery of exchange of the trideuteromethyl group when using methane, ammonia was used for later analyses. The determination of propantheline ion in urine and plasma after administration of propantheline bromide to man is described.