Premium
Replacement of a chlorine with a methylsulfonyl group in the metabolism of propachlor (2‐chloro‐ N ‐isopropylacetanilide)
Author(s) -
Bakke J. E.,
Feil V. J.,
Price C. E.
Publication year - 1976
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200030506
Subject(s) - mercapturic acid , urine , chemistry , chlorine , metabolism , cysteine , chromatography , chlorine atom , biochemistry , organic chemistry , medicinal chemistry , enzyme
Abstract Urine from rats and sheep given single oral doses of [ 14 C]propachlor contained 14 C metabolites in which the chlorine of propachlor was replaced by a methylsulfonyl group. Methylsulfonyl‐containing metabolites were also isolated from the urine of rats given an intraperitoneal dose of the cysteine conjugate of [ 14 C]propachlor; this indicated that the methylsulfonyl‐containing metabolites resulted from metabolic reactions subsequent to the mercapturic acid pathway.