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Gas chromatographic mass spectrometric evaluation of free organic acids in human saliva
Author(s) -
Ward M. E.,
Politzer I. R.,
Laseter J. L.,
Alam S. Q.
Publication year - 1976
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200030207
Subject(s) - chromatography , saliva , chemistry , gas chromatography , environmental chemistry , biochemistry
Excellent resolution and subsequent identification of free organic acids extracted from mixed, unstimulated human saliva was obtained by gas chromatography using high resolution open tubular glass capillary columns coupled with mass spectrometry computer instrumentation. In addition to the organic acids, identified as their trimethylsilyl derivatives, the presence of 2,6‐di‐ t ‐butylcresol—a food preservative—and cholesterol was established by mass spectrometry. The effects of aspirin ingestion as well as diurnal variation were studied to demonstrate the possible clinical significance of this noninvasive approach to metabolic profiling.