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The identification of 6‐methoxy 8‐aminoquionoline as a metabolite of primaquine in man
Author(s) -
Baty J. D.,
Evans D. A. Price,
Robinson P. A.
Publication year - 1975
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200020605
Subject(s) - primaquine , identification (biology) , metabolite , medicine , biology , malaria , ecology , chloroquine , immunology
The identification of 6‐methoxy 8‐aminoquinoline as a metabolite of Primaquine, an important antimalarial drug, is described. The metabolite is present in urine, plasma and erythrocytes following drug ingestion. It was identified by mass fragmentography of its 1 H and 2 H acetate and the acetate produced from authentic material. No evidence of further metabolites was obtained.