Analysis of organochlorine metabolites in crude extracts by high resolution photoplate mass spectrometry | Zendy

Safe S. | Zendy; Platonow N. | Zendy; Hutzinger O. | Zendy; Jamieson W. D. | Zendy

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Analysis of organochlorine metabolites in crude extracts by high resolution photoplate mass spectrometry

Author(s) -

Safe S.,

Platonow N.,

Hutzinger O.,

Jamieson W. D.

Publication year - 1975

Publication title -

biomedical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0306-042X

DOI - 10.1002/bms.1200020407

Subject(s) - metabolite , chemistry , chromatography , mass spectrometry , urine , xenobiotic , gas chromatography–mass spectrometry , high resolution , environmental chemistry , metabolomics , biochemistry , enzyme , geology , remote sensing

High resolution photoplate mass spectrometry has been used to examine crude goat urine extracts to determine the fate of organochlorine xenobiotics in these animals. Using a direct introduction temperature controlled probe the crude urine extracts were analyzed and the presence of oxygenated metabolites of 4‐chlorobiphenyl and 4,4′‐dichlorobiphenyl were confirmed in goats; analyses of urine extracts from goats injected with the commercial Aroclor mixtures 1254 and 5460 confirmed the formation of oxygenated penta‐, tetra‐ and monochlorobiphenyl metabolites and an oxygenated dichloroterphenyl metabolite, respectively. This technique was particularly useful in the analysis of complex mixtures of metabolites.

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