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Mass spectrometric identification of an N ‐oxide formed by incubation of N , N ‐dimethyl‐ 5H ‐dibenzo[ a , d ]cycloheptene‐Δ 5,γ ‐propylamine with rat liver microsomes
Author(s) -
Belvedere G.,
Rovei V.,
Pantarotto C.,
Frigerio A.
Publication year - 1974
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200010507
Subject(s) - cycloheptene , chemistry , chromatography , incubation , metabolite , mass spectrometry , microsome , organic chemistry , biochemistry , enzyme
On incubation with rat liver microsomes, N , N ‐dimethyl‐ 5H ‐dibenzo[ a , d ]cycloheptene‐Δ 5,γ ‐propylamine is converted to the N ‐oxide. The identification of this metabolite has been achieved by the use of gas chromatography, mass spectrometry and thin‐layer chromatography.