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Phospholipids in pulmonary alveolar proteinosis
Author(s) -
Einolf W. Noel,
Fenselau Catherine
Publication year - 1974
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200010310
Subject(s) - pulmonary alveolar proteinosis , reagent , chemistry , chromatography , hydrolysis , pulmonary alveolus , mass spectrometry , gas chromatography–mass spectrometry , phosphate , medicine , biochemistry , lung , respiratory disease , organic chemistry
Gas chromatography–mass spectrometry has been used to identify the phosphate diester backbones of two classes of phospholipids previously unrecognized in washings from human lungs. Washings were analyzed from two patients with pulmonary alveolar proteinosis and also from two pairs of normal lungs washed postmortem. α‐Glycerophosphorylglycerol and α‐glycerophosphorylinositol were identified in all four cases following hydrolysis of the fatty acid esters and treatment with trimethylsilylating reagent.