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High resolution mass spectroscopic analysis of methylated tolbutomide derivatives
Author(s) -
Sabih Khalid
Publication year - 1974
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200010303
Subject(s) - dimethyl sulfate , chemistry , mass spectrum , nitrogen , sulfonamide , methylation , derivative (finance) , nitrogen atom , aryl , tolbutamide , medicinal chemistry , mass spectrometry , resolution (logic) , high resolution , fast atom bombardment , stereochemistry , organic chemistry , chromatography , dna , biochemistry , biology , alkyl , remote sensing , artificial intelligence , geology , computer science , financial economics , economics , group (periodic table) , diabetes mellitus , endocrinology
The methyl derivative of tolbutamide, obtained by the action of dimethyl sulfate, has been subjected to g.c.‐m.s. at high resolution. From the mass spectrum it is deduced that methylation of the sulfonamide nitrogen atom has occurred. During the loss of SO 2 from the molecular ion, aryl rearrangement to both oxygen and nitrogen occurs in the ratio of 1:2.