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Detection and quantitative analysis of amphetamine
Author(s) -
Danielson Terry J.,
Boulton Alan A.
Publication year - 1974
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200010302
Subject(s) - amphetamine , urine , chemistry , chromatography , quantitative analysis (chemistry) , derivative (finance) , biochemistry , medicine , dopamine , financial economics , economics
The high resolution mass spectrometric integrated ion current procedure has been used to identify and quantitate amphetamine, isolated as its dansyl derivative, as it is found after addition to urine and in tissues of the rat following intraperitoneal injection. A linear relationship between amphetamine and ion current response has been established at least in the range 5 × 10 −12 to 5 × 10 −7 g, and as little as 8 × 10 −13 mol of amphetamine in urine may be detected.