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Liquid chromatography‐mass spectrometry. II—continuous monitoring
Author(s) -
Arpino Patrick,
Baldwin M. A.,
McLafferty F. W.
Publication year - 1974
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200010117
Subject(s) - mass spectrometry , chromatography , liquid chromatography–mass spectrometry , chemistry
Monitoring of solutes eluted from a liquid chromatograph is possible by continuous introduction of the effluent solution into the ion source of a chemical ionization mass spectrometer. Detection sensitivities in the nanogram range are possible for a wide variety of solutes and solvents. Auxiliary techniques which have proved valuable for g.c.‐m.s. also appear to be applicable to l.c.m.s.