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Recent progress in the development of derivatization reagents having a benzofurazan structure
Author(s) -
Santa Tomofumi,
Fukushima Takeshi,
Ichibangase Tomoko,
Imai Kazuhiro
Publication year - 2008
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.945
Subject(s) - reagent , derivatization , chemistry , chromatography , high performance liquid chromatography , organic chemistry
Chemical derivatization is often used to enhance the detectability of the target compounds and to improve the separation efficiency in high‐performance liquid chromatography (HPLC). In this review, we describe the recent progress in the development of derivatization reagents having a benzofurazan structure, namely, the fluorogenic reagents, water‐soluble reagents, reagents for the analysis of peptides and proteins, and reagents for mass spectrometric detection. The application of these reagents to bio‐samples is also briefly described. Copyright © 2007 John Wiley & Sons, Ltd.