Synthesis of 4‐[2‐( N , N ‐dimethylamino)ethylaminosulfonyl]‐7‐ N ‐methylhydrazino‐2,1,3‐benzoxadiazole (DAABD‐MHz) as a derivatization reagent for aldehydes in liquid chromatography/electrospray ionization–tandem mass spectrometry | Zendy

Santa Tomofumi | Zendy; AlDirbashi Osama Y | Zendy; Ichibangase Tomoko | Zendy; Rashed Mohamed S | Zendy; Fukushima Takeshi | Zendy; Imai Kazuhiro | Zendy

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Synthesis of 4‐[2‐( N , N ‐dimethylamino)ethylaminosulfonyl]‐7‐ N ‐methylhydrazino‐2,1,3‐benzoxadiazole (DAABD‐MHz) as a derivatization reagent for aldehydes in liquid chromatography/electrospray ionization–tandem mass spectrometry

Author(s) -

Santa Tomofumi,

AlDirbashi Osama Y,

Ichibangase Tomoko,

Rashed Mohamed S,

Fukushima Takeshi,

Imai Kazuhiro

Publication year - 2008

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.903

Subject(s) - chemistry , derivatization , reagent , chromatography , electrospray ionization , mass spectrometry , dissociation (chemistry) , tandem mass spectrometry , electrospray , organic chemistry

Benzofurazan derivatization reagent, 4‐[2‐( N , N ‐dimethylamino)ethylaminosulfonyl]‐7‐ N ‐methylhydrazino‐2,1,3‐benzoxadiazole (DAABD‐MHz), for aldehydes in liquid chromatography/electrospray ionization–tandem mass spectrometry (LC/ESI‐MS/MS), was synthesized. DAABD‐MHz reacted with aliphatic aldehydes under mild conditions. The generated derivatives were separated on a reversed‐phase column and detected by ESI‐MS/MS with detection limits of 30–60 fmol on‐column. Upon collision‐induced dissociation, a single and intense fragment ion at m / z 151 was observed. These results suggested that DAABD‐MHz was suitable as a derivatization reagent in LC/ESI‐MS/MS. Copyright © 2007 John Wiley & Sons, Ltd.

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