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Quantitative gas chromatography/time‐of‐flight mass spectrometry: a review
Author(s) -
Williamson Leah N.,
Bartlett Michael G.
Publication year - 2007
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.847
Subject(s) - mass spectrometry , chemistry , chromatography , gas chromatography , time of flight mass spectrometry , analytical chemistry (journal) , mass spectrum , spectrometer , physics , ion , organic chemistry , quantum mechanics , ionization
Time‐of‐flight (TOF) instruments have recently gained popularity in quantitative analyses. Normally, TOF mass spectrometers are used for accurate mass measurements for empirical formula verification. However, over the past decade, they have been used quantitatively as well. Because of the fast separations and narrow peaks that result from gas chromatography separations, scanning mass spectrometers are not ideal detectors. TOF mass spectrometers, however, have the ability to collect spectra at a faster rate. Two‐dimensional gas chromatography has also been introduced to further resolve peaks from complex matrices. Two‐dimensional gas chromatography results in a faster separation as well as narrower peaks. This paper reviews the methods currently in the literature for the quantitation of compounds using one‐ and two‐dimensional gas chromatography and TOF mass spectrometry detection. Copyright © 2007 John Wiley & Sons, Ltd.