LC‐MS characterization of efficacy substances in serum of experimental animals treated with  Sophora flavescens  extracts | Zendy

Ye Guan | Zendy; Zhu HaiYan | Zendy; Li ZhiXiong | Zendy; Ma ChunHui | Zendy; Fan MingSong | Zendy; Sun ZhaoLin | Zendy; Huang ChengGang | Zendy

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LC‐MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts

Author(s) -

Ye Guan,

Zhu HaiYan,

Li ZhiXiong,

Ma ChunHui,

Fan MingSong,

Sun ZhaoLin,

Huang ChengGang

Publication year - 2007

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.805

Subject(s) - sophora flavescens , matrine , oxymatrine , chemistry , chromatography , electrospray ionization , sophora , traditional medicine , mass spectrometry , pharmacology , biology , medicine , traditional chinese medicine , alternative medicine , pathology

Anti‐DHBV (duck hepatitis B virus) activity was found in the aqueous extracts of Sophora flavescens Ait. in vivo . Liquid chromatography/electrospray ionization ion trap mass spectrometry was applied to characterize the components in duck serum after oral administration of S. flavescens extract. Oxymatrine ( 1 ), sophoranol ( 2 ), sophoridine ( 3 ) and matrine ( 4 ) were identified in the serum. Further research on the four compounds was evaluated for their antiviral activity against HBV (hepatitis B virus) in cell culture. The results suggested that oxymatrine, sophoranol and matrine were the efficacy substances for anti‐HBV activity in aqueous extracts of S. flavescens Ait. Copyright © 2007 John Wiley & Sons, Ltd.

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