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Detection of perfluorocarbons in blood by headspace solid‐phase microextraction combined with gas chromatography/mass spectrometry
Author(s) -
Mathurin JeanCharles,
Ceaurriz Jacques de,
Audran Michel,
Krafft MariePierre
Publication year - 2001
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.79
Subject(s) - chemistry , solid phase microextraction , chromatography , mass spectrometry , detection limit , gas chromatography–mass spectrometry , extraction (chemistry) , gas chromatography , ion trap , analytical chemistry (journal) , ion mobility spectrometry
A new method of detection of perfluorocarbon molecules (PFCs) in blood sample has been established. After an extraction and pre‐concentration step performed by headspace solid‐phase microextraction (HS‐SPME), the PFCs are detected by gas chromatography‐mass spectrometry (GC/MS) with an ion trap mass spectrometer in MS and MS/MS modes. The influence of different parameters on the SPME process is discussed. The limit of detection and the linearity of the procedure have been determined for two PFCs. Copyright © 2001 John Wiley & Sons, Ltd. Abbreviations used : EI electron impactEPO erythropoietinFDC F‐decalineHS‐SPME headspace solid‐phase extractionIOC International Olympic CommitteeLOD Limit of detectionPDMS polydimethylsiloxanePFCs perfluorocarbon molecules