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Identification of flurbiprofen and its photoproducts in methanol by gas chromatography–mass spectrometry
Author(s) -
Chao SuHui,
Ho HsinTsung,
Chen FuAn,
Lin PenYuan,
Yu YiChun,
Wu AnBang
Publication year - 2007
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.789
Subject(s) - chemistry , methanol , flurbiprofen , decarboxylation , mass spectrometry , ketone , chromatography , photochemistry , gas chromatography , irradiation , organic chemistry , catalysis , medicine , physics , nuclear physics , pharmacology
Abstract A sample of 10 m m flurbiprofen in methanol (or ethanol) was photoirradiated with sixteen 8 W low‐pressure quartz mercury lamps irradiated at 306 nm in a Panchum PR‐2000 photochemical reactor. In total, four major photoproducts derived from each sample were observed from the HPLC chromatogram. The photoproducts were separated and their structures elucidated by various spectroscopic methods. Alternatively, using GC‐MS, 11 major photoproducts were observed. A reaction scheme of flurbiprofen in methanol is proposed: the photochemical reaction routes occur mainly via esterification and decarboxylation, followed by oxidation with singlet oxygen to produce a ketone, alcohols and other derivatives. Copyright © 2007 John Wiley & Sons, Ltd.