Direct resolution of (±)‐ephedrine and atropine into their enantiomers by impregnated TLC | Zendy

Bhushan R. | Zendy; Martens J. | Zendy; Arora Meenakshi | Zendy

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Direct resolution of (±)‐ephedrine and atropine into their enantiomers by impregnated TLC

Author(s) -

Bhushan R.,

Martens J.,

Arora Meenakshi

Publication year - 2001

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.55

Subject(s) - chemistry , ephedrine , chromatography , enantiomer , vapours , resolution (logic) , reagent , acetonitrile , silica gel , thin layer chromatography , tartaric acid , methanol , atropine , organic chemistry , artificial intelligence , neuroscience , computer science , citric acid , biology , medicine , anesthesia

Direct resolution of (±)‐ephedrine and atropine into their enantiomers was achieved by normal‐phase thin layer chromatography on silica gel plates impregnated with optically pure L ‐tartaric acid and L ‐histidine, respectively, as chiral selectors. The mobile phases enabling successful resolution were different combinations of acetonitrile–methanol–water. The spots were detected with iodine vapours and the detection limits were 2 and 6 µg, respectively, in terms of the racemate. The effects of concentration of the impregnating reagent, temperature and pH on resolution have been studied. Copyright © 2001 John Wiley & Sons, Ltd.

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