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Synthesis and evaluation of a new biselector s ‐triazine based chiral stationary phase for enantioselective HPLC: potentiality of the approach and perspectives
Author(s) -
Lecci Cristina,
Iuliano Anna
Publication year - 2005
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.503
Subject(s) - enantioselective synthesis , chemistry , chiral stationary phase , chromatography , triazine , stationary phase , high performance liquid chromatography , chiral column chromatography , combinatorial chemistry , organic chemistry , catalysis
A s ‐triazine scaffold bearing a free and a protected amino group was used for connecting two different chiral auxiliaries, whose enantiodiscriminating capabilities in enantioselective chromatography are well documented. A biselector system was synthesized and, after linkage to silica gel, used for the chromatographic resolution of different racemic analytes, chosen among the compounds resolved by the two different isolated chiral auxiliaries. The obtained chromatographic results were compared with literature data related to the use of the two chiral stationary phases (CSPs) whose chiral moieties constitute the biselector CSP, allowing us to gain useful information about potentialities and limitations of this approach for obtaining independent CSPs having broader applicability with respect to the classical independent monoselector CSPs. Copyright © 2005 John Wiley & Sons, Ltd.