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Purification of carbon‐11 PET radiotracers from unlabeled precursors by preparative HPLC and SPE
Author(s) -
Zheng QiHuang,
Mock Bruce H.
Publication year - 2005
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.494
Subject(s) - chemistry , solid phase extraction , chromatography , high performance liquid chromatography , extraction (chemistry) , positron emission tomography , nuclear medicine , medicine
Abstract A general methodology for the rapid purification of carbon‐11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid‐phase extraction (SPE) techniques are described which can separate some commonly used radiopharmaceuticals such as [ 11 C]raclopride, [ 11 C] β ‐CFT and [ 11 C]choline from their unlabeled precursors. Copyright © 2005 John Wiley & Sons, Ltd.