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A review of bioanalytical methods for chronic lymphocytic leukemia drugs and metabolites in biological matrices
Author(s) -
P S Suresh,
Trivedi Ravi Kumar,
Srinivas Nuggehally R.,
Mullangi Ramesh
Publication year - 2020
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.4742
Subject(s) - bioanalysis , chemistry , chronic lymphocytic leukemia , chromatography , tandem mass spectrometry , drug , liquid chromatography–mass spectrometry , leukemia , mass spectrometry , pharmacology , medicine
Quantitation of drugs used for the treatment of chronic lymphocytic leukemia in various biological matrices during both pre‐clinical and clinical developments is very important, often in routine therapeutic drug monitoring. The first developed methods for quantitation were traditionally done on LC in combination with either UV or fluorescence detection. However, the emergence of LC with mass spectrometry in tandem in early 1990s has revolutionized the quantitation as it has provided better sensitivity and selectivity within a shorter run time; therefore it has become the choice of method for the analysis of various drugs. In this article, an overview of various bioanalytical methods (HPLC or LC–MS/MS) for the quantification of drugs for the treatment of chronic lymphocytic leukemia, along with applicability of these methods, is given.