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QSAR characterization of new synthesized hydantoins with antiproliferative activity
Author(s) -
Tot Kristina,
Lazić Anita,
Božić Biljana,
Mandić Anamarija,
Djaković Sekulić Tatjana
Publication year - 2019
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.4539
Subject(s) - lipophilicity , chemistry , quantitative structure–activity relationship , molecular descriptor , substituent , solvation , chromatography , molecular model , in silico , pharmacokinetics , stereochemistry , molecule , organic chemistry , pharmacology , biochemistry , medicine , gene
Abstract Hydantois have been identified as constituents of a number of pharmacologically active molecules. In the present study, we have examined in vitro antiproliferative activity against human colon cancer cell lines HCT‐116 of three series of 3‐(4‐substituted benzyl)‐hydantoins with various substituent attached in position 5 of the hydantoin ring. Since the investigated compounds have recently been synthesized and show antiproliferative activity, a good understanding of the properties of the potential drug responsible for their pharmacokinetics is an important goal for their further development. One of the important properties is lipophilicity. Lipophilicity has been assessed by reversed‐phase liquid chromatography (high‐performance thin‐layer chromatography and high‐pressure liquid chromatography) by means of direct and indirect (using calibration curve) methods. Chromatographic lipophilicity indices in addition to calculated log P values were compared by hierarchical cluster analysis. The linear solvation energy relationship approach was used to understand and compare the types and relative strength of the molecular interactions that occur in the chromatographic as well as in the n ‐octanol–water partitioning systems. Finally, correlation between in silico pharmacokinetic predictors and antiproliferative activity was examined. Preliminary quantitative structure–activity relationship modeling indicates that pharmacokinetic predictors capture only one‐quarter of all chemical features that are important for antiproliferative activity itself. Among selected descriptors are chromatographic lipophilicity indices.