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Determination of ephedrine and related compounds in pharmaceutical preparations by ion chromatography with direct conductivity detection
Author(s) -
Ouyang Jin,
Gao Xiaoyin,
Baeyens Willy R.G.,
Delanghe Joris R.
Publication year - 2005
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.448
Subject(s) - pseudoephedrine , ephedrine , chemistry , chromatography , detection limit , column chromatography , pharmacology , medicine
Abstract An ion chromatographic method with conductivity detection for the simultaneous determination of ephedrine, pseudoephedrine and norephedrine was developed. A mixture of 2.0 mmol/L HNO 3 and 2% (v/v) acetonitrile was used as eluent. The three ephedrine‐like compounds were separated and determined within 20 min. The linear ranges were 0.08–50 µg/mL for ephedrine, 0.08–40 µg/mL for pseudoephedrine and 0.06–40 µg/mL for norephedrine. The detection limits were 0.03 µg/mL for ephedrine and pseudoephedrine, and 0.02 µg/mL for norephedrine. The method has been applied successfully to the determination of these sympathomimetics in pharmaceutical preparations and in Ephedra herbs. Copyright © 2005 John Wiley & Sons, Ltd.