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Comparative pharmacokinetics of three alkaloids in normal and acute hepatitis rats after oral administration of Yanhuanglian total alkaloids extract
Author(s) -
Dai Guoliang,
Sun Bingting,
Wu Lei,
Gao Xiaojun,
Song Shanshan,
Sun Hong,
Ju Wenzheng
Publication year - 2018
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.4329
Subject(s) - pharmacokinetics , acute hepatitis , berberine , pharmacology , hepatitis , oral administration , chemistry , palmatine , medicine
Acute hepatitis is a severe inflammatory disease with high mortality rates. Dehydrocavidine (DC), berberine (BB) and palmatine (PT), the bioactive components of Yanhuanglian total alkaloids extract (YTAE), may play important roles in its protective effect against acute hepatitis. The present study was designed to compare the pharmacokinetic properties of DC, BB and PT after oral administration of YTAE in normal and acute hepatitis rats. The plasma pharmacokinetic profiles of three major bioactive alkaloids from YTAE were analyzed using an LC‐MS/MS method. It was found that the pharmacokinetic parameters of DC, BB and PT represented a statistically significant difference ( p ˂ 0.05) between the normal rats and the acute hepatitis rats after administration of YTAE. The results indicated that the C max , T 1/2 β and AUC of DC, BB and PT in acute hepatitis rats were significantly increased, whereas the CL and V d values were remarkably decreased ( p ˂ 0.05) over those of the normal rats. The results suggested that the pharmacokinetic behavior of the active constituents from YTAE could be changed when it was used in acute hepatitis animals, which provide a meaningful basis for developing a clinical dosage regimen in the treatment of acute hepatitis by YTAE.