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Comparison of plasma pharmacokinetics of Tanreqing solution between intratracheal aerosolization and intravenous injection in rats
Author(s) -
Li Cui,
Liu Siyu,
Luo Gan,
Wang Guohua,
Zhang Baoxian,
Nie Qixia
Publication year - 2018
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.4116
Subject(s) - aerosolization , chemistry , pharmacokinetics , chromatography , plasma concentration , pharmacology , plasma , anesthesia , inhalation , medicine , physics , quantum mechanics
A rapid ultra high performance liquid chromatography tandem mass spectrometry method was developed for the simultaneous analysis of baicalin, oroxylin A‐7‐ O‐β ‐ d ‐glucoronide and chlorogenic acid in rats plasma, and applied to comparison of pharmacokinetics of Tanreqing solution between intratracheal aerosolization and intravenous injection. Results of the analytical method validation assay showed high sensitivity, accuracy and suitable recovery. Results of pharmacokinetics showed similar decline phases for baicalin, oroxylin A‐7‐ O‐β ‐ d ‐glucoronide and chlorogenic acid in two different delivery routes. The half‐lives of intratracheal aerosolization and intravenous injection were 0.90 and 1.22 h for baicalin, 0.47 and 0.17 h for oroxylin A‐7‐ O‐β ‐ d ‐glucoronide and 0.22 and 0.13 h for chlorogenic acid, and this implies that compounds were retained in the lung for a relatively short time. This study was the first to provide important pharmacokinetics information for traditional Chinese medicine delivery to the lung.