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Determination of thiocyanate as a biomarker of tobacco smoke constituents in selected biological materials of human origin
Author(s) -
Narkowicz Sylwia,
Jaszczak Ewa,
Polkowska Żaneta,
Kiełbratowska Bogumiła,
Kotłowska Alicja,
Namieśnik Jacek
Publication year - 2018
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.4111
Subject(s) - thiocyanate , chemistry , biomonitoring , tobacco smoke , chromatography , cigarette smoke , biological materials , extraction (chemistry) , environmental chemistry , saliva , cotinine , biomarker , smoke , nicotine , human health , urine , meconium , toxicology , organic chemistry , biochemistry , biology , medicine , pregnancy , fetus , genetics , environmental health , neuroscience , biological system
Abstract In order to protect human health, it is necessary to biomonitor toxic substances originating from tobacco smoke in biological materials sampled from persons with different exposures to tobacco smoke constituents. Thiocyanate anion is a biomarker of exposure to tobacco smoke components which is characterized by a relatively long half‐life in the human body, i.e. 6 days. In this work, we present the results of thiocyanate determinations performed on samples of placenta, meconium, saliva, breast milk, sweat and blood. The placenta samples were subjected to accelerated solvent extraction with water. The thiocyanate concentrations were determined using ion chromatography. The analyzed biological materials were compared with regard to their applicability for biomonitoring toxic substances originating from tobacco smoke. The highest mean concentrations of thiocyanate were observed in the samples of biological materials collected from active smokers.