Pharmacokinetics and metabolism of olerciamide A from   Portulaca oleracea   L. in rats by UHPLC‐UV and UHPLC‐ESI‐Q‐TOF/MS | Zendy

Ying Zheming | Zendy; Li Cuiyu | Zendy; Gao Mingzhe | Zendy; Ying Xixiang | Zendy; Yang Guanlin | Zendy

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Pharmacokinetics and metabolism of olerciamide A from Portulaca oleracea L. in rats by UHPLC‐UV and UHPLC‐ESI‐Q‐TOF/MS

Author(s) -

Ying Zheming,

Li Cuiyu,

Gao Mingzhe,

Ying Xixiang,

Yang Guanlin

Publication year - 2018

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.4061

Subject(s) - chemistry , pharmacokinetics , chromatography , portulaca , bioavailability , quadrupole time of flight , high performance liquid chromatography , mass spectrometry , urine , oral administration , electrospray , electrospray ionization , pharmacology , biochemistry , traditional medicine , medicine

The aim of this study was to elucidate the pharmacokinetics of olerciamide A in rats after oral and intravenous administration of Portulaca oleracea L. extract by a simple and rapid ultra high‐performance liquid chromatography method with bergapten as internal standard. The pharmacokinetic results indicated that olerciamide A was rapidly distributed with a time to peak concentration of 30 min after oral administration and presented a low oral absolute bioavailability of 4.57%. The metabolism of olerciamide A in rats was also investigated using ultra‐high‐performance liquid chromatography electrospray coupled with quadrupole–time of flight mass spectrometry to elucidate the reason for the low absolute bioavailability of olerciamide A and seven metabolites of oleraciamide A were found in rat plasma and urine.

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