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Pharmacokinetic comparison of two phenolic acids after oral administration of Typhae pollen to normal rats and rats with acute cold blood stasis
Author(s) -
Pan Yingni,
Zhang Wenjie,
Zhang Wei,
Bai Xuewei,
Ren Shumeng,
Zheng Jiang,
Wang Dongmei,
Liu Xiaoqiu
Publication year - 2017
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.4028
Subject(s) - blood stasis , pharmacokinetics , chemistry , bioavailability , pharmacology , oral administration , absorption (acoustics) , vanillic acid , chromatography , traditional chinese medicine , medicine , pathology , physics , alternative medicine , acoustics
Typhae Pollen, dried pollen of Typha angustifolia L., Typha orientalis Presl or other plants of the same genus (Typhaeceae), has the effect of activating the circulation to cure blood stasis in traditional Chinese Medicine. The purpose of this study was to set up an ultra‐high performance liquid chromatography method that could determine p‐ hydroxybenzoic acid and vanillic acid simultaneously in rat plasma, and to compare their pharmacokinetics in normal rats and rats with acute cold blood stasis, and further to investigate the influence of different dosages of oral administration. The pharmacokinetic parameters obtained showed that both of the phenolic acids had a higher bioavailability in rats with cold blood stasis than that in normal rats with a higher area under the concentration–time curve and longer mean residence time, and the high dose oral administration group had a higher capacity in blood stasis rats than in normal rats. These results reminded us that changes in health condition could alter the absorption and elimination of both phenolic acids in vivo , and the pharmacokinetic study under pathological conditions provides important information for more rational drug use in clinical situations.