Switching from an analogous to a stable isotopically labeled internal standard for the LC‐MS/MS quantitation of the novel anticancer drug Kahalalide F signiﬁcantly improves assay performance | Zendy

Stokvis E. | Zendy; Rosing H. | Zendy; LópezLázaro L. | Zendy; Schellens J. H. M. | Zendy; Beijnen J. H. | Zendy

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Switching from an analogous to a stable isotopically labeled internal standard for the LC‐MS/MS quantitation of the novel anticancer drug Kahalalide F signiﬁcantly improves assay performance

Author(s) -

Stokvis E.,

Rosing H.,

LópezLázaro L.,

Schellens J. H. M.,

Beijnen J. H.

Publication year - 2004

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.392

Subject(s) - chemistry , chromatography , drug , pharmacology , medicine

The importance of a stable isotopically labeled (SIL) internal standard for the quantitative LC‐MS/MS assay for Kahalalide F in human plasma is highlighted. Similar results can be expected for other LC‐MS/MS assays. Therefore, we emphasize the need for an SIL internal standard for accurate and precise LC‐MS/MS assays of drugs in biological matrices. Copyright © 2004 John Wiley & Sons, Ltd.

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