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Switching from an analogous to a stable isotopically labeled internal standard for the LC‐MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance
Author(s) -
Stokvis E.,
Rosing H.,
LópezLázaro L.,
Schellens J. H. M.,
Beijnen J. H.
Publication year - 2004
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.392
Subject(s) - chemistry , chromatography , drug , pharmacology , medicine
The importance of a stable isotopically labeled (SIL) internal standard for the quantitative LC‐MS/MS assay for Kahalalide F in human plasma is highlighted. Similar results can be expected for other LC‐MS/MS assays. Therefore, we emphasize the need for an SIL internal standard for accurate and precise LC‐MS/MS assays of drugs in biological matrices. Copyright © 2004 John Wiley & Sons, Ltd.