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HPTLC and magnetochromatography of new complexes of carboxylates with transition metals or rare earth elements and their ligands – study of lipophilicity
Author(s) -
Malinowska Irena,
Wronka Agnieszka,
Ferenc Wiesława
Publication year - 2017
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.3872
Subject(s) - lipophilicity , chemistry , thin layer chromatography , acetonitrile , acetone , chelation , chromatography , phase (matter) , molecular descriptor , quantitative structure–activity relationship , organic chemistry , stereochemistry
Nineteen new complexes of carboxylates with transition and rare elements as central ions and their ligands were characterized by chromatographic analyses. The parameter of relative lipophilicity ( R M0 ) of the tested compounds was determined experimentally by the reversed‐phase high‐performance thin layer chromatography method with mixtures of various organic modifiers (acetonitrile, acetone, dioxane) and water as a mobile phase. The extrapolated R M0 values were compared with the log P values calculated from the molecular structures of tested solutes. Similarities between the lipophilicity indices were analysed by principal component analysis and linear regression. Thin‐layer chromatography combined with a magnetic field has been proposed as a complementary method for determination of lipophilicity of the investigated compounds. The chromatograms in the field and outside it were developed simultaneously in two identical chromatographic chambers. One of them was placed in the external magnetic field of 0.4 T inductivity. We proved that chelation causes a drastic change in compound lipophilicity, but all complexes did not exhibit enhanced activity as compared with the parent ligand. Also in the magnetic field the retention of some complexes changed, which means that the presence of the field influences the physicochemical properties of the compounds and their interactions with the stationary phase.