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Comparisons of pharmacokinetics and NO‐releasing of nitrofibriate and fenofibrate after oral administration in rats
Author(s) -
Yang Yujie,
Cheng Qiang,
Liu Xiumei,
Liu Zejuan,
Li Tingting,
Jiang Xuehua,
Wang Ling
Publication year - 2016
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.3777
Subject(s) - fenofibrate , pharmacokinetics , chemistry , pharmacology , in vivo , oral administration , metabolite , nitric oxide , active metabolite , chromatography , medicine , biochemistry , organic chemistry , microbiology and biotechnology , biology
Nitrofibriate, a new compound of hypolipidemic, is modified based on fenofibrate. Both of them are used for prevention and treatment of cardiovascular diseases. In this study, an accurate and sensitive analytical method of reversed‐phase high‐performance liquid chromatography was developed to determine fenofibric acid, which is an active metabolite of both nitrofibriate and fenofibrate in rat plasma. This method was validated and successfully applied to pharmacokinetic study of nitrofibriate and fenofibrate after oral administration. The results suggested that the pharmacokinetic behavior of nitrofibriate followed a nonlinear process, while fenofibrate was linear, demonstrating that the two drugs were different in pharmacokinetic behaviors. Moreover, the effect of fenofibrate and nitrofibriate on releasing NO in rat serum was explored. This study showed that nitrofibriate, as a nitric oxide donor, could slowly release nitric oxide in vivo . This study provided a biopharmaceutical basis for further study of nitrofibriate.