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Analysis of the pharmacokinetics and metabolism of aloe‐emodin following intravenous and oral administrations in rats
Author(s) -
Yu ChungPing,
Shia ChiSheng,
Lin HuiJu,
Hsieh YowWen,
Lin ShiuanPey,
Hou YuChi
Publication year - 2016
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.3735
Subject(s) - aloe emodin , chemistry , pharmacokinetics , pharmacology , chromatography , metabolism , emodin , biochemistry , medicine
Aloe‐emodin, a natural polyphenolic anthraquinone, has shown various beneficial bioactivities in vitro . The aim of this study was to investigate the pharmacokinetics and metabolism of aloe‐emodin. Aloe‐emodin was intravenously and orally administered to rats. The concentrations of aloe‐emodin and rhein, a metabolite of aloe‐emodin, were determined by HPLC method prior to and after hydrolysis with β ‐glucuronidase and sulfatase/ β ‐glucuronidase. The results showed that the systemic exposures of aloe‐emodin and its metabolites were ranked as aloe‐emodin glucuronides (G) > rhein sulfates (S) > aloe‐emodin > rhein and rhein G when aloe‐emodin was given intravenously. In contrast, when aloe‐emodin was administered orally, the parent form of aloe‐emodin was not absorbed per se, and the systemic exposures of its metabolites were ranked as aloe‐emodin G > rhein G > rhein. In conclusion, the metabolites of aloe‐emodin are more important than the parent form for the bioactivities in vivo . Copyright © 2016 John Wiley & Sons, Ltd.