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Urinary metabolomic study of systemic lupus erythematosus based on gas chromatography/mass spectrometry
Author(s) -
Yan Bei,
Huang Jia,
Dong Fan,
Yang Liping,
Huang Cibo,
Gao Ming,
Shi Aixin,
Zha Weibin,
Shi Luyi,
Hu Xin
Publication year - 2016
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.3734
Subject(s) - metabolomics , chemistry , urinary system , gas chromatography–mass spectrometry , urine , metabolome , metabolic pathway , microbiome , mass spectrometry , metabolism , pathogenesis , chromatography , medicine , biochemistry , bioinformatics , biology
Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous organ and system manifestations. In this study, urinary metabolic alterations related to SLE were investigated by performing gas chromatography/mass spectrometry (GC/MS) based metabolomics and multivariate statistical analysis. Patients with SLE and healthy controls could be clearly differentiated in view of the metabolic abnormity in urine. Among 70 identified endogenous metabolites, 23 metabolites were dramatically increased in SLE patients, which involved in several key metabolic pathways including energy metabolism, nucleotide metabolism, oxidative stress and gut‐microbiome‐derived metabolism. This noninvasive and GC/MS‐based metabolomic technique is a promising and potent strategy for identifying novel biomarkers and understanding pathogenesis of SLE. Copyright © 2016 John Wiley & Sons, Ltd.