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Pharmacokinetics of tecomin in rats after intragastric and intravenous administration
Author(s) -
Guo Lina,
Peng Yushuai,
Zhao Can,
Yang Xin,
Liu Lijia,
Wang Rufeng
Publication year - 2016
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.3604
Subject(s) - pharmacokinetics , chemistry , in vivo , pharmacology , in vitro , metabolism , enteral administration , biotransformation , transformation (genetics) , chromatography , biochemistry , enzyme , medicine , parenteral nutrition , microbiology and biotechnology , biology , gene
The pharmacokinetics of tecomin, which is a potential bioactive compound from the flowers of Trollius chinensis , was studied. The results showed that this compound was easily absorbed and rapidly metabolized into veratric acid in vivo , and then the latter was eliminated slowly. In addition, the simulant in vitro gastrointestinal transformation experiments demonstrated that the basic enteral environment and intestinal bacterial flora also contributed to the metabolism of tecomin to veratric acid. Copyright © 2015 John Wiley & Sons, Ltd.