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Amino acids as chiral auxiliaries in cyanuric chloride‐based chiral derivatizing agents for enantioseparation by liquid chromatography
Author(s) -
Batra Sonika,
Bhushan Ravi
Publication year - 2014
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.3305
Subject(s) - cyanuric chloride , chemistry , enantiomer , diastereomer , chiral derivatizing agent , derivatization , chromatography , amino acid , organic chemistry , acryloyl chloride , resolution (logic) , dansyl chloride , enantiomeric excess , chiral resolution , chiral auxiliary , enantioselective synthesis , combinatorial chemistry , high performance liquid chromatography , chiral column chromatography , catalysis , polymer , biochemistry , monomer , acrylate , artificial intelligence , computer science
This review summarizes and critically evaluates the recent research on application of amino acids and amino acid amides as chiral auxiliaries in cyanuric chloride (CC) based chiral derivatizing agents (CDRs), used in the indirect approach for enantiomeric resolution. Methods of synthesis of such CDRs, methods for synthesis of diastereomers of a variety of racemic compounds and parameters of liquid chromatographic separation, along with their prospects and their limitations in indirect enantioresolution, are discussed. Application of the said CDR(s) and the technical approach to be used that are discussed should be beneficial for control of enantiomeric purity in pharmaceutical industry, verification of enantiomeric ratio of commercial formulations and the development of methods for indirect resolution of a variety of chiral compounds. Derivatization methods are particularly required when a chromophore is to be introduced in low UV absorbing molecules, for their detection. Copyright © 2014 John Wiley & Sons, Ltd.